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Home / Primary Antibodies / Polyclonal Antibodies

TNPO2 antibody

SKU : BHA10808836

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Mfr.No.	FNab08844
Background	Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex(NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus(By similarity).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).
Host	Rabbit
Immunogen	transportin 2
Isotype	IgG
Molecular Weight	90-100 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	O14787
Gene Id	30000
Research Area	Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF
Description	ELISA ; WB ; IF
Tested Application	WB: 1:500-1:2000; IF: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808836	FNab08844	100ug	$260		Add to Cart

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