Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Host
Rabbit
Immunogen
tumor necrosis factor, alpha-induced protein 8
Isotype
IgG
Molecular Weight
21-23 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
O95379
Gene Id
25816
Research Area
Stem Cells, Immunology, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)