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Home / Primary Antibodies / Polyclonal Antibodies

TNF-alpha antibody

SKU : BHA10808813

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Mfr.No.	FNab08821
Alternative Names	Cachectin ; DIF ; TNF ; TNFa ; TNFalpha ; TNFA ; TNFSF2 ; Tumornecrosisfactor
Background	TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor(TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme(TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Categories	Primary Antibodies
Clonality	polyclonal
Description	TNF, as also known as TNF-alpha, or cachectin, is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. It is expressed as a 26 kDa membrane bound protein and is then cleaved by TNF-alpha converting enzyme (TACE) to release the soluble 17 kDa monomer, which forms homotrimers in circulation. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.
Host	Rabbit
Immunogen	tumor necrosis factor(TNF superfamily, member 2)
Isotype	IgG
Molecular Weight	26KD
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Cachectin, DIF, TNF, TNF a, TNF alpha, TNFA, TNFSF2, Tumor necrosis factor

Uniprot	P01375
Research Area	Developmental biology, Immunology, Cardiovascular, Signal Transduction
Weight	26kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, IHC

Description

ELISA ; IHC

Dilution

IHC	1:20-1:200

Tested Application

WB: 1:200-1:1000; IHC: 1:50-1:500

Manual	FNab08821.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808813	FNab08821	100ug	$280		Add to Cart

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