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Home / Primary Antibodies / Polyclonal Antibodies

TMEM173 antibody

SKU : BHA10808751

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Mfr.No.	FNab08759
Alternative Names	ERIS ; MITA{ECO:0000303 ; PubMed:18818105
Background	This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263).
Host	Rabbit
Immunogen	transmembrane protein 173
Isotype	IgG
Molecular Weight	39 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	ERIS, hMITA, hSTING, MITA, MPYS, NET23, SAVI, STING

Uniprot	Q86WV6
Gene Id	340061
Research Area	Epigenetics, Cancer, Immunology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, FC, IF, IP
Description	ELISA ; WB ; IHC ; FC ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab08759.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808751	FNab08759	100ug	$260		Add to Cart

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