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Home / Primary Antibodies / Polyclonal Antibodies

TLK2 antibody

SKU : BHA10808717

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Mfr.No.	FNab08725
Background	This gene encodes a nuclear serine/threonine kinase that was first identified in Arabidopsis. The encoded protein is thought to function in the regulation of chromatin assembly in the S phase of the cell cycle by regulating the levels of a histone H3/H4 chaperone. This protein is associated with double-strand break repair of DNA damage caused by radiation. Pseudogenes of this gene are present on chromosomes 10 and 17. Alternate splicing results in multiple transcript variants.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A AND ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy.
Host	Rabbit
Immunogen	tousled-like kinase 2
Isotype	IgG
Molecular Weight	87 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	HsHPK, PKU-ALPHA

Uniprot	Q86UE8
Gene Id	11011
Research Area	Signal Transduction, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF
Description	ELISA ; WB ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100

Manual	FNab08725.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808717	FNab08725	100ug	$260		Add to Cart

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