Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.
Host
Rabbit
Immunogen
transducin-like enhancer of split 1
Isotype
IgG
Molecular Weight
83kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
E(Sp1) homolog, ESG, ESG1, GRG1, TLE1
Uniprot
Q04724
Gene Id
7088
Research Area
Developmental biology, Signal Transduction, Metabolism, Cancer, Immunology
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)