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Home / Primary Antibodies / Polyclonal Antibodies

TIMELESS antibody

SKU : BHA10810339

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Mfr.No.	FNab10381
Background	Plays an important role in the control of DNA replication, maintenance of replication fork stability, maintenance of genome stability throughout normal DNA replication and in the regulation of the circadian clock. Involved in the determination of period length and in the DNA damage-dependent phase advancing of the circadian clock. Negatively regulates CLOCK\|NPAS2-ARTNL/BMAL1\|ARTNL2/BMAL2-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Forms a complex with TIPIN and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. Timeless promotes TIPIN nuclear localization. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.
Clonality	polyclonal
Host	Rabbit
Immunogen	timeless homolog(Drosophila)
Immunogen Region	timeless homolog(Drosophila)
Isotype	IgG
Molecular Weight	140-160kd
Reactivity	Human
Recommended Dilution	WB: 1:500-1:2000
Synonyms	FLJ12640, FLJ20714, hTIM, Protein timeless homolog, TIM, TIM1, TIMELESS, timeless homolog(Drosophila), TIMELESS1

Uniprot	Q9UNS1
Gene Id	8914
Research Area	Developmental biology, Metabolism, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10381.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810339	FNab10381	100ug	$280		Add to Cart

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