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Home / Primary Antibodies / Polyclonal Antibodies

TIA1 antibody

SKU : BHA10808677

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Mfr.No.	FNab08685
Background	The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
Host	Rabbit
Immunogen	TIA1 cytotoxic granule-associated RNA binding protein
Isotype	IgG
Molecular Weight	54 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	P31483
Gene Id	7072
Research Area	Cancer, Immunology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:100; IF: 1:20 - 1:100

Manual	FNab08685.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808677	FNab08685	100ug	$260		Add to Cart

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