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Home / Primary Antibodies / Polyclonal Antibodies

TFEB antibody

SKU : BHA10808619

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Mfr.No.	FNab08627
Alternative Names	BHLHE35
Background	TFEB specifically recognizes and binds to E-box sequences, which required dimerization with itself or another MiT/TFE family member. It plays a role in T-cell-dependent antibody responses to activated CD4+ T-cells and thymus-dependent humoral immunity once associated with TFE3. It also activates lysosomal gene by binding the CLEAR-box sequence in the regulatory region. It involves in the signal transduction processes required for normal vascularization of the placenta. This is a rabbit polyclonal antibody raised against the full length of human TFEB. The calcualted molecular weight of TFEB is 53 kDa, but modified TFEB is about 65-70 kDa.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T- cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Host	Rabbit
Immunogen	transcription factor EB
Isotype	IgG
Molecular Weight	65-70kd
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	AlphaTFEB, bHLHe35, TCFEB, TFEB, transcription factor EB

Uniprot	P19484
Gene Id	7942
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IF, IP
Description	ELISA ; WB ; IHC ; IF ; IP
Tested Application	WB: 1:500-1:2000; IHC: 1:50-1:200; IF: 1:20-1:200

Manual	FNab08627.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808619	FNab08627	100ug	$260		Add to Cart

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