Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine(6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
Clonality
polyclonal
Host
Rabbit
Immunogen
synuclein, beta
Immunogen Region
synuclein, beta
Isotype
IgG
Molecular Weight
14-18 kDa
Reactivity
Human, Mouse
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500
Synonyms
Beta synuclein, SNCB, synuclein, beta, SYUB
Uniprot
Q16143
Gene Id
6620
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:50-1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10048.pdf" target="_blank">Data Sheet</ a>