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Home / Primary Antibodies / Polyclonal Antibodies

STAT3 antibody

SKU : BHA10808290

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Mfr.No.	FNab08298
Alternative Names	APRF
Background	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Categories	Primary Antibodies
Cellular Localization	Cytoplasm, Nucleus
Clonality	polyclonal
Description	Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
Host	Rabbit
Immunogen	signal transducer and activator of transcription 3 (acute-phase response factor)
Isotype	IgG
Molecular Weight	85 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Cytoplasm, Nucleus
Synonyms	Acute phase response factor, APRF, HIES, STAT3

Uniprot	P40763
Gene Id	6774
Research Area	Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells
Weight	88kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, FC, IP

Description

ELISA ; WB ; IHC ; IF ; FC ; IP

Dilution

WB	1:1000-1:10000
IP	1:1000-1:10000
IHC	1:50-1:200
IF	1:10-1:100

Tested Application

WB: 1:200 - 1:500; IHC: 1:50 - 1:200; IF: 1:10-1:100

Manual	FNab08298.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808290	FNab08298	100ug	$260		Add to Cart

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