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Home / Primary Antibodies / Polyclonal Antibodies

SSB antibody

SKU : BHA10808238

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Mfr.No.	FNab08246
Background	The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).
Host	Rabbit
Immunogen	Sjogren syndrome antigen B (autoantigen La)
Isotype	IgG
Molecular Weight	47 kDa
Reactivity	Human
Regulatory	RUO

Uniprot	P05455
Gene Id	6741
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, WB, IF
Description	ELISA ; IHC ; WB ; IF
Tested Application	WB: 1:500 - 1:1000; IHC: 1:100 - 1:200

Manual	FNab08246.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808238	FNab08246	100ug	$260		Add to Cart

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