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Home / Primary Antibodies / Polyclonal Antibodies

SRGAP2 antibody

SKU : BHA10808217

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Mfr.No.	FNab08225
Alternative Names	ARHGAP34 ; FNBP2 ; Forminbindingprotein2 ; KIAA0456 ; SRGAP2 ; srGAP3
Background	RAC1 GTPase activating protein(GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Categories	Primary Antibodies
Clonality	polyclonal
Description	RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia.
Host	Rabbit
Immunogen	SLIT-ROBO Rho GTPase activating protein 2
Isotype	IgG
Molecular Weight	120-140 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ARHGAP34, FNBP2, Formin binding protein 2, KIAA0456, SRGAP2, srGAP3

Uniprot	O75044
Gene Id	23380
Research Area	Signal Transduction
Weight	121 kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:500-1:5000

Tested Application

WB: 1:500-1:5000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808217	FNab08225	100ug	$260		Add to Cart

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