GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Categories
Primary Antibodies
Clonality
polyclonal
Description
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Host
Rabbit
Immunogen
SLIT-ROBO Rho GTPase activating protein 1
Isotype
IgG
Molecular Weight
130 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
ARHGAP13, FLJ22166, KIAA1304, SRGAP1
Uniprot
Q7Z6B7
Gene Id
57522
Research Area
Signal Transduction, Neuroscience
Weight
130 kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)