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Home / Primary Antibodies

Src Antibody (F45526)

SKU : BHA17100883

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NSJ Bioreagents

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Mfr.No.	F45526, F45526-0.08ML, F45526-0.4ML
Antigen	Src
Clonality	Polyclonal
Description	Non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, plays an important role in osteoclastic bone resorption. Both the formation of a SRC-PTK2B complex, and SRC kinase activity are necessary for this function. Once it is recruited to the activated integrins, by PTK2B, it phosphorylates CBL which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances DDX58/RIG-I-elicited antiviral signaling.
Formulation	In 1X PBS, pH 7.4, with 0.09% sodium azide
Host	Rabbit
Immunogen Region	A portion of amino acids 98-125 from the mouse protein was used as the immunogen for this Src antibody.
Isotype	Ig
Predicted Reactivity	Mouse
Reactivity	Mouse
Recombinant	No

Uniprot	P05480

Format	Antigen affinity purified
Purification	Antigen affinity
Storage	Aliquot the Src antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Applications	WB, ELISA
Dilution	Western blot: 1:1000

Product Manual	Data Sheet

No Description Available.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHA17100883-1	F45526-0.08ML	0.08ml	$165		Add to Cart
BHA17100883-2	F45526-0.4ML	0.4ml	$379		Add to Cart

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