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Home / Primary Antibodies / Polyclonal Antibodies

SPTLC1 antibody

SKU : BHA10808198

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Mfr.No.	FNab08206
Alternative Names	HSAN ; HSAN1 ; HSN1 ; LBC1 ; LCB1 ; LCB1 ; Serinepalmitoyltransferase1 ; SPT1 ; SPT1 ; SPTI ; SPTLC1
Background	This gene encodes a member of the class-II pyridoxal-phosphate-dependent aminotransferase family. The encoded protein is the long chain base subunit 1 of serine palmitoyltransferase. Serine palmitoyltransferase converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate and is the key enzyme in sphingolipid biosynthesis. Mutations in this gene were identified in patients with hereditary sensory neuropathy type 1. Alternatively spliced variants encoding different isoforms have been identified. Pseudogenes of this gene have been defined on chromosomes 1, 6, 10, and 13.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Host	Rabbit
Immunogen	serine palmitoyltransferase, long chain base subunit 1
Isotype	IgG
Molecular Weight	53 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HSAN, HSAN1, HSN1, LBC1, LCB 1, LCB1, Serine palmitoyltransferase 1, SPT 1, SPT1, SPTI, SPTLC1

Uniprot	O15269
Gene Id	10558
Research Area	Metabolism
Weight	55kd

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IP

Description

ELISA ; WB ; IHC ; IP

Dilution

WB	1:1000-1:10000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab08206.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808198	FNab08206	100ug	$260		Add to Cart

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