Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras. Inhibits Ras-independent, but not Ras-dependent, activation of RAF1.
Host
Rabbit
Immunogen
sprouty homolog 4(Drosophila)
Isotype
IgG
Molecular Weight
35-38 kDa
Reactivity
Human
Regulatory
RUO
Synonyms
Protein sprouty homolog 4, sprouty homolog 4(Drosophila), Spry 4, SPRY4
Uniprot
Q9C004
Gene Id
81848
Research Area
Developmental biology, Signal Transduction
Weight
35 kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)