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Home / Primary Antibodies / Polyclonal Antibodies

SPARC antibody

SKU : BHA10808145

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Mfr.No.	FNab08153
Alternative Names	ON
Background	This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.
Host	Rabbit
Immunogen	secreted protein, acidic, cysteine-rich (osteonectin)
Isotype	IgG
Molecular Weight	35 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	ON

Uniprot	P09486
Gene Id	6678
Research Area	Stem Cells, Immunology, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab08153.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808145	FNab08153	100ug	$240		Add to Cart

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