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Home / Primary Antibodies / Polyclonal Antibodies

SNAI1 antibody

SKU : BHA10808043

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Mfr.No.	FNab08051
Alternative Names	SNAH
Background	Involved in induction of the epithelial to mesenchymal transition(EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate(TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Host	Rabbit
Immunogen	snail homolog 1(Drosophila)
Isotype	IgG
Molecular Weight	29KD
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	Protein sna, Protein snail homolog 1, SLUGH2, SNA, SNAH, SNAI1, snail homolog 1(Drosophila), SNAIL1, Zinc finger protein SNAI1

Uniprot	O95863
Gene Id	6615
Research Area	Developmental biology, Metabolism, Cardiovascular, Stem Cells, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:500-1:5000; IHC: 1:50-1:500

Manual	FNab08051.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10808043	FNab08051	100ug	$260		Add to Cart

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