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Home / Primary Antibodies / Polyclonal Antibodies

SMAD3 antibody

SKU : BHA10807986

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Mfr.No.	FNab07994
Alternative Names	MADH3，hMAD3 ; hSMAD3 ; HSPC193 ; HsT17436 ; JV152 ; MADhomolog3 ; Mad3 ; MothersagainstDPPhomolog3 ; SMAD3 ; SMADfamilymember3 ; SMAD3
Background	The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.
Categories	Primary Antibodies
Clonality	polyclonal
Description	SMAD3, also named as hMAD 3 or Mad3, is a 425 amino acid protein, which contains one MH1 domain and one MH2 domain. SMAD3 localizes in the nucleus and cytoplasm. SMAD3 plays an essential role in development and maintenance of self-tolerance and is a critical mediator of the TGFB signaling pathway. SMAD3 is involved in TGFB dependent regulation of steroidogenesis and in T-cell response to TGFB.
Host	Rabbit
Immunogen	SMAD family member 3
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	MADH3, hMAD 3, hSMAD3, HSPC193, HsT17436, JV15 2, MAD homolog 3, Mad3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3, SMAD3

Uniprot	P84022
Gene Id	4088
Research Area	Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Cancer, Stem Cells
Weight	48 kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF

Description

ELISA ; WB ; IHC ; IF

Dilution

WB	1:200-1:2000

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab07994.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807986	FNab07994	100ug	$280		Add to Cart

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