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Home / Primary Antibodies / Polyclonal Antibodies

SMAD1 antibody

SKU : BHA10807984

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Mfr.No.	FNab07992
Alternative Names	BSP1 ; MADH1 ; MADR1
Background	The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression.
Host	Rabbit
Immunogen	SMAD family member 1
Isotype	IgG
Molecular Weight	54 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	BSP1, MADH1, MADR1

Uniprot	Q15797
Gene Id	4086
Research Area	Epigenetics, Developmental biology, Signal Transduction, Metabolism, Cardiovascular, Cancer, Stem Cells

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IP
Description	ELISA ; WB ; IF ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab07992.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807984	FNab07992	100ug	$260		Add to Cart

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