Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
Categories
Primary Antibodies
Cellular Localization
Membrane
Clonality
polyclonal
Description
Important in metal transport, in particular iron. Can also transport manganese, cobalt, cadmium, nickel, vanadium and lead. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution. May serve to import iron into the mitochondria.
Host
Rabbit
Immunogen
solute carrier family 11(proton-coupled divalent metal ion transporters), member 2
Isotype
IgG
Molecular Weight
60-70, 75-100 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Subcellular Location
Cell membrane
Synonyms
DCT1, DMT1, NRAMP2
Uniprot
P49281
Gene Id
4891
Research Area
Signal Transduction
Weight
66kDa
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)