This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.
Clonality
polyclonal
Host
Rabbit
Immunogen
S-phase kinase-associated protein 1
Immunogen Region
S-phase kinase-associated protein 1
Isotype
IgG
Molecular Weight
19 kDa
Reactivity
Human, Rat
Recommended Dilution
WB: 1:200 - 1:2000; IHC: 1:50 - 1:200
Synonyms
EMC19, OCP2, SKP1A, TCEB1L
Uniprot
P63208
Gene Id
6500
Research Area
Cell Division and Proliferation, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:200 - 1:2000; IHC: 1:50 - 1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10039.pdf" target="_blank">Data Sheet</ a>