NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF-kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. (UniProt)
Formulation
Antibody in PBS with 50% Glycerol and 0.03% ProClin 300
Host
Mouse
Immunogen Region
A human recombinant protein was used as the immunogen for this SIRT6 antibody.
Isotype
IgG1
Predicted Reactivity
Human, Mouse, Rat, Primate
Reactivity
Primate, Human, Mouse, Rat
Recombinant
No
Antigen
SIRT6
Uniprot
Q8N6T7
Clone No
6C9-D10-D3
Format
Purified
Purification
Protein G affinity
Storage
Store the SIRT6 antibody at -20°C.
Applications
WB, ICC, IF, IP
Dilution
Western blot: 1:500,ICC/Immunofluorescence: 1:100,Immunoprecipitation: suitable