This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5, 10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Interconversion of serine and glycine (PubMed:8505317, PubMed:24698160).
Host
Rabbit
Immunogen
serine hydroxymethyltransferase 1 (soluble)
Isotype
IgG
Molecular Weight
43 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Uniprot
P34896
Gene Id
6470
Research Area
Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)