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Home / Primary Antibodies / Polyclonal Antibodies

RPA2 antibody

SKU : BHA10807384

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Mfr.No.	FNab07392
Alternative Names	REPA2 ; RPA32 ; RPA34
Background	RPA2 (replication protein A2, 32kDa) is a protein-coding gene. Diseases associated with RPA2 include familial melanoma, and xeroderma pigmentosum, group a. GO annotations related to this gene include protein phosphatase binding and protein N-terminus binding. An important paralog of this gene is RPA4.
Categories	Primary Antibodies
Clonality	polyclonal
Description	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.
Host	Rabbit
Immunogen	replication protein A2, 32kDa
Isotype	IgG
Molecular Weight	32 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	REPA2, RPA32, RPA34

Uniprot	P15927
Gene Id	6118
Research Area	Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP
Description	ELISA ; WB ; IHC ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:100; IP: 1:50 - 1:200

Manual	FNab07392.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807384	FNab07392	100ug	$260		Add to Cart

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