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Home / Primary Antibodies / Polyclonal Antibodies

RNASEL antibody

SKU : BHA10807323

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Mfr.No.	FNab07331
Alternative Names	RNS4
Background	This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831).
Host	Rabbit
Immunogen	ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
Isotype	IgG
Molecular Weight	110 kDa
Reactivity	Human, Rat, Mouse
Regulatory	RUO
Synonyms	RNS4

Uniprot	Q05823
Gene Id	6041
Research Area	Immunology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IF, IHC
Description	ELISA ; WB ; IF ; IHC
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab07331.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807323	FNab07331	100ug	$240		Add to Cart

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