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Home / Primary Antibodies / Monoclonal Antibodies

RENALASE antibody

SKU : BHA10807231

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Mfr.No.	FNab07239
Alternative Names	C10orf59 ; MAOC ; MonoamineoxidaseC ; RENALASE ; RNLS
Background	RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS.
Categories	Primary Antibodies
Cellular Localization	Secreted
Clonality	monoclonal
Description	RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circulates in blood and modulates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity. (PMID:15841207 ) This antibody is specific to RNLS.
Host	Mouse
Immunogen	chromosome 10 open reading frame 59
Isotype	IgG1
Molecular Weight	38 kDa
Reactivity	Human
Regulatory	RUO
Subcellular Location	Secreted
Synonyms	C10orf59, MAO C, Monoamine oxidase C, RENALASE, RNLS

Uniprot	Q5VYX0
Gene Id	55328
Clone No	9C9
Research Area	Cardiovascular, Metabolism
Weight	38kDa

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:1000-1:10000
IHC	1:20-1:200

Tested Application

WB: 1:500-1:3000; IHC: 1:20-1:200

Manual	FNab07239.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807231	FNab07239	100ug	$260		Add to Cart

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