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Home / Primary Antibodies / Polyclonal Antibodies

REDD1 specific antibody

SKU : BHA10807220

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Mfr.No.	FNab07228
Background	REDD1, also named as RTP801 and DDIT4, belongs to the DDIT4 family.Its function?Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1(mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes(By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication(By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death.This antibody is specific to the REDD1.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	DNA-damage-inducible transcript 4
Isotype	IgG
Molecular Weight	35 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	HIF-1 responsive protein RTP801,Protein regulated in development and DNA damage response 1,REDD-1,REDD1, RTP801,DDIT4

Uniprot	Q9NX09
Gene Id	54541
Research Area	Epigenetics, Immunology, Cardiovascular

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IHC, IP, WB
Description	ELISA ; IHC ; IP ; WB
Tested Application	WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:50-1:200

Manual	FNab07228.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807220	FNab07228	100ug	$260		Add to Cart

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