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Home / Primary Antibodies / Polyclonal Antibodies

RBL2 antibody

SKU : BHA10807149

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Mfr.No.	FNab07157
Alternative Names	RB2
Background	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys- 20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
Host	Rabbit
Immunogen	retinoblastoma-like 2(p130)
Isotype	IgG
Molecular Weight	130 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	FLJ26459, P130, pRb2, Rb2, RBL2, RBR 2, retinoblastoma like 2(p130), Retinoblastoma like protein 2

Uniprot	Q08999
Gene Id	5934
Research Area	Developmental biology, Cell Division and Proliferation, Metabolism, Immunology, Cancer

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA
Description	ELISA
Tested Application	WB: 1:200-1:2000

Manual	FNab07157.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807149	FNab07157	100ug	$260		Add to Cart

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