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Home / Primary Antibodies / Polyclonal Antibodies

RAD18 antibody

SKU : BHA10807067

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Mfr.No.	FNab07075
Alternative Names	RNF73
Background	The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
Categories	Primary Antibodies
Clonality	polyclonal
Description	E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap- filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono- ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.
Host	Rabbit
Immunogen	RAD18 homolog
Isotype	IgG
Molecular Weight	80 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	RNF73

Uniprot	Q9NS91
Gene Id	56852
Research Area	Epigenetics, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

Manual	FNab07075.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807067	FNab07075	100ug	$240		Add to Cart

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