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Home / Primary Antibodies / Monoclonal Antibodies

Rac1 antibody

SKU : BHA10807057

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Mfr.No.	FNab07065
Alternative Names	TC25
Background	RAC1b, also named as TC25, belongs to the small GTPase superfamily and Rho family. RAC1 is a plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, it binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles.
Categories	Primary Antibodies
Clonality	monoclonal
Description	Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. Stimulates PKN2 kinase activity. In concert with RAB7A, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. In glioma cells, promotes cell migration and invasion. In podocytes, promotes nuclear shuttling of NR3C2; this modulation is required for a proper kidney functioning. Required for atypical chemokine receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of cofilin (CFL1) and for up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3. Isoform B has an accelerated GEF-independent GDP/GTP exchange and an impaired GTP hydrolysis, which is restored partially by GTPase-activating proteins. It is able to bind to the GTPase-binding domain of PAK but not full-length PAK in a GTP- dependent manner, suggesting that the insertion does not completely abolish effector interaction.
Host	Mouse
Immunogen	ras-related C3 botulinum toxin substrate 1(rho family, small GTP binding protein Rac1)
Isotype	IgG1
Molecular Weight	21KD
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	MIG5, p21 Rac1, RAC1, RAC1b, Ras like protein TC25, TC 25, TC25

Uniprot	P63000
Gene Id	5879
Clone No	5D9
Research Area	Immunology, Cardiovascular, Signal Transduction

Form	liquid
Format	liquid
Purification	Protein A+G purification
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IP
Description	ELISA ; WB ; IP
Tested Application	WB: 1:1000-1:4000; IP: 1:200-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Manual	FNab07065.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10807057	FNab07065	100ug	$280		Add to Cart

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