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Home / Primary Antibodies / Polyclonal Antibodies

RAB17 antibody

SKU : BHA10806989

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Mfr.No.	FNab06997
Background	The Rab subfamily of small GTPases plays an important role in the regulation of membrane trafficking. RAB17 is an epithelial cell-specific GTPase (Lutcke et al., 1993 (PubMed 8486736)).
Categories	Primary Antibodies
Clonality	polyclonal
Description	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post- endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.
Host	Rabbit
Immunogen	RAB17, member RAS oncogene family
Isotype	IgG
Molecular Weight	23 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	Q9H0T7
Gene Id	64284
Research Area	Signal Transduction

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, IF
Description	ELISA ; IF
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab06997.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806989	FNab06997	100ug	$240		Add to Cart

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