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Home / Primary Antibodies / Polyclonal Antibodies

PTP1B antibody

SKU : BHA10806919

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Mfr.No.	FNab06927
Alternative Names	PTP1B ; PTP1B ; PTPN1
Background	The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Categories	Primary Antibodies
Cellular Localization	endoplasmic reticulum, Membrane
Clonality	polyclonal
Description	PTPN1(protein tyrosine phosphatase, non-receptor type 1) is also named as PTP1B, PTP-1B and belongs to the protein-tyrosine phosphatase family and non-receptor class 1 subfamily. PTPN1 is involved in the regulation of several important physiological pathways, which regulates both insulin and leptin signaling, and interacts with the epidermal-and platelet-derived growth factor receptors(PMID:20101100). The gene might harbor variants influencing susceptibility to insulin resistance and type 2 diabetes(PMID:15919813).
Host	Rabbit
Immunogen	protein tyrosine phosphatase, non-receptor type 1
Isotype	IgG
Molecular Weight	50 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Subcellular Location	Endoplasmic reticulum, Membrane
Synonyms	PTP 1B, PTP1B, PTPN1

Uniprot	P18031
Gene Id	5770
Research Area	Signal Transduction, Metabolism, Neuroscience
Weight	50kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC, IF, IP

Description

ELISA ; WB ; IHC ; IF ; IP

Dilution

WB	1:500-1:5000
IP	1:200-1:2000
IHC	1:20-1:200
IF	1:10-1:100

Tested Application

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Manual	FNab06927.pdf

No Description Available.

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806919	FNab06927	100ug	$240		Add to Cart

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