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Home / Primary Antibodies / Polyclonal Antibodies

PTP1B antibody

SKU : BHA10810228

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Mfr.No.	FNab10253
Background	The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene.
Clonality	polyclonal
Host	Rabbit
Immunogen	protein tyrosine phosphatase, non-receptor type 1
Immunogen Region	protein tyrosine phosphatase, non-receptor type 1
Isotype	IgG
Molecular Weight	50 kDa
Reactivity	Human, Rat
Recommended Dilution	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200
Subcellular Location	Endoplasmic reticulum, Membrane
Synonyms	PTP 1B, PTP1B, PTPN1

Uniprot	P18031
Gene Id	5770
Research Area	Signal Transduction, Metabolism, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10253.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810228	FNab10253	100ug	$240		Add to Cart

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