Receptor for prostaglandin E2(PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems(By similarity).
Clonality
polyclonal
Host
Rabbit
Immunogen
prostaglandin E receptor 3(subtype EP3)
Immunogen Region
prostaglandin E receptor 3(subtype EP3)
Isotype
IgG
Molecular Weight
55 kDa, 70 kDa
Reactivity
Human, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Synonyms
EP3, EP3 I, EP3 II, EP3 III, EP3 IV, EP3e, PGE receptor EP3 subtype, PGE2 R, PGE2 receptor EP3 subtype, Prostanoid EP3 receptor, PTGER3, PE2R3
Uniprot
P43115
Gene Id
5733
Research Area
Signal Transduction
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:20-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10093.pdf" target="_blank">Data Sheet</ a>