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Home / Primary Antibodies / Polyclonal Antibodies

PTEN antibody

SKU : BHA10810233

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Mfr.No.	FNab10258
Background	This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by this gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of this gene is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Clonality	polyclonal
Host	Rabbit
Immunogen	phosphatase and tensin homolog
Immunogen Region	phosphatase and tensin homolog
Isotype	IgG
Molecular Weight	55 kDa
Reactivity	Human, Rat
Recommended Dilution	WB: 1:500 - 1:2000
Synonyms	MMAC1, TEP1

Uniprot	P60484
Research Area	Cell Division and Proliferation, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Stem Cells, Neuroscience

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500 - 1:2000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10258.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810233	FNab10258	100ug	$260		Add to Cart

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