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Home / Primary Antibodies / Polyclonal Antibodies

PSMF1 antibody

SKU : BHA10806890

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Mfr.No.	FNab06898
Background	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.
Host	Rabbit
Immunogen	proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Isotype	IgG
Molecular Weight	30 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO

Uniprot	Q92530
Gene Id	9491
Research Area	Developmental biology

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Manual	FNab06898.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806890	FNab06898	100ug	$240		Add to Cart

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