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Home / Primary Antibodies / Polyclonal Antibodies

PSMD14 antibody

SKU : BHA10806878

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Mfr.No.	FNab06886
Alternative Names	PAD1 ; POH1 ; PSMD14 ; rpn11
Background	Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks(DSBs): acts as a regulator of non-homologous end joining(NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Metalloprotease component of the 26S proteasome that specifically cleaves 'Lys-63'-linked polyubiquitin chains. The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.
Host	Rabbit
Immunogen	proteasome(prosome, macropain) 26S subunit, non-ATPase, 14
Isotype	IgG
Molecular Weight	35 kDa
Reactivity	Human
Regulatory	RUO
Synonyms	PAD1, POH1, PSMD14, rpn11

Uniprot	O00487
Gene Id	10213
Research Area	Metabolism
Weight	35kDa

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications

ELISA, WB, IHC

Description

ELISA ; WB ; IHC

Dilution

WB	1:200-1:2000
IHC	1:20-1:200

Tested Application

WB: 1:200-1:2000; IHC: 1:20-1:200

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806878	FNab06886	100ug	$280		Add to Cart

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