Protein phosphatase 3 (PPP3, formerly PP2B, Calcineurin), a serine/ threonine protein phosphatase, is a heterodimer composed of one catalytic subunit (PPP3C, Calcineurin A) and one regulatory subunit (PPP3R, Calcineurin B). PPP3R has two isoforms, PPP3R1 and PPP3R2. PPP3Rl is ubiquitously expressed in different tissues and is coded by the PPP3R1 gene which was mapped recently to human chromosome 2. PPP3Rl has four functional calcium-binding sites.
Categories
Primary Antibodies
Clonality
polyclonal
Description
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Host
Rabbit
Immunogen
protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform
Isotype
IgG
Molecular Weight
15 kDa
Reactivity
Human, Mouse, Rat
Regulatory
RUO
Synonyms
CNA2, CNB
Uniprot
P63098
Gene Id
5534
Research Area
Immunology, Signal Transduction, Metabolism
Form
liquid
Format
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)