Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Clonality
polyclonal
Host
Rabbit
Immunogen
peroxisome proliferator-activated receptor delta
Immunogen Region
peroXisome proliferator-actIVated receptor delta
Isotype
IgG
Molecular Weight
55 kDa
Reactivity
Human, Rat
Recommended Dilution
WB: 1:200-1:2000; IHC: 1:50-1:200
Synonyms
PPARD, PPAR beta, NUCII, FAAR, PPAR delta
Uniprot
Q03181
Gene Id
5467
Research Area
Developmental biology, Signal Transduction, Metabolism
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:200-1:2000; IHC: 1:50-1:200
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10132.pdf" target="_blank">Data Sheet</ a>