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Home / Primary Antibodies / Polyclonal Antibodies

PLK4 antibody

SKU : BHA10806542

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Mfr.No.	FNab06550
Alternative Names	SAK ; STK18
Background	This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Categories	Primary Antibodies
Clonality	polyclonal
Description	Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124).
Host	Rabbit
Immunogen	polo-like kinase 4 (Drosophila)
Isotype	IgG
Molecular Weight	115 kDa
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	SAK, STK18

Uniprot	O00444
Gene Id	10733
Research Area	Developmental biology, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC
Description	ELISA ; WB ; IHC
Tested Application	WB: 1:200 - 1:2000; IHC: 1:50 - 1:100

Manual	FNab06550.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806542	FNab06550	100ug	$240		Add to Cart

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