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Home / Primary Antibodies / Polyclonal Antibodies

PKM1-specific antibody

SKU : BHA10806486

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Mfr.No.	FNab06494
Background	PKM, also named as OIP3, PK2, PK3, PKM, p58, THBP1, CTHBP and Tumor M2-PK, belongs to the pyruvate kinase family. It is glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate(PEP) to ADP, generating ATP. It stimulates POU5F1-mediated transcriptional activation. PKM plays a general role in caspase independent cell death of tumor cells. PKM has 2 isoforms named PKM1 and PKM2. By the upstream metabolite fructose-1,6-bisphosphate, PKM1 is a constitutively active enzyme.The primary pyruvate kinase isoform before tumour development is PK-M1; however, the primary isoform from four independent tumours is PK-M2(PMID:18337823). This antibody is specific to PKM1 isoform.
Categories	Primary Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	PKM2 pyruvate kinase, muscle
Isotype	IgG
Molecular Weight	58KD
Reactivity	Human, Mouse, Rat
Regulatory	RUO
Synonyms	CTHBP, OIP 3, OIP3, Opa interacting protein 3, p58, PK2, PK3, PKM, PKM1, PK-M1, PKM1 pyruvate kinase, muscle, Pyruvate kinase 2/3, Pyruvate kinase isozymes M1/M2, Pyruvate kinase muscle isozyme, TCB, THBP1, Tumor M2 PK

Antigen	PKM1-specific
Uniprot	P14618
Research Area	Stem Cells, Cancer, Cardiovascular, Metabolism

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB, IHC, IP, IF
Description	ELISA ; WB ; IHC ; IP ; IF
Tested Application	WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:100-1:400; IF: 1:20-1:200

Manual	FNab06494.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806486	FNab06494	100ug	$260		Add to Cart

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