Protein kinase C(PKC) is a family of serine-and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC gamma is a neuron-specific member of the classical PKCs and is activated and translocated to subcellular regions as a result of various stimuli, including diacylglycerol synthesis, increased intracellular Ca(2+) and phorbol esters. Defects in this protein have been associated with spinocerebellar ataxia type 14(SCA14), an autosomal dominant neurodegenerative disease.
Clonality
polyclonal
Host
Rabbit
Immunogen
protein kinase C, gamma
Immunogen Region
protein kinase C, gamma
Isotype
IgG
Molecular Weight
78 kDa
Reactivity
Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000; IHC: 1:100-1:500
Synonyms
PKC gamma, PKCC, PKCG, PRKCG, Protein kinase C gamma type, protein kinase C, gamma, SCA14
Uniprot
P63318
Research Area
Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000; IHC: 1:100-1:500
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10007.pdf" target="_blank">Data Sheet</ a>