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Home / Primary Antibodies / Polyclonal Antibodies

Piezo1 antibody

SKU : BHA10806427

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Mfr.No.	FNab06435
Alternative Names	FAM38A ; KIAA0233
Background	Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).
Categories	Primary Antibodies
Clonality	polyclonal
Description	Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).
Host	Rabbit
Immunogen	family with sequence similarity 38, member A
Isotype	IgG
Molecular Weight	250kd
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	FAM38A, KIAA0233

Uniprot	Q92508
Gene Id	9780

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:200-1:1000; IHC: 1:50-1:500

Manual	FNab06435.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806427	FNab06435	100ug	$280		Add to Cart

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