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Home / Primary Antibodies / Polyclonal Antibodies

phospho-TDP43 (409/410) antibody

SKU : BHA10806393

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Mfr.No.	FNab06401
Background	TDP-43 is a 414 amino acid (aa) nuclear DNA and RNA-binding protein which regulates transcription and splicing. TDP-43 is aberrantly expressed in most forms of amylotrophic lateral sclerosis and frontotemporal lobar degeneration. In these cases it is absent from the nucleus and accumulates, along with a truncated 25kDa form, in ubiquitin-containing inclusion bodies. In pathological tissues, TDP-43 is highly phosphorylated and Ser409/410 is the main phosphorylation site. Among the TDP-43 protein fragments, the 25kDa fragment is also highly phosphorylated and widely believed to be pathogenic. This antibody is a rabbit polyclonal antibody recognizing TDP-43 only when phosphorylated at 409/410. This antibody detects phosphorylated forms of TDP-43 as well as the cleavage product of 25 kDa.
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Host	Rabbit
Immunogen	TAR DNA binding protein
Isotype	IgG
Molecular Weight	48 kDa
Reactivity	Human, Mouse
Regulatory	RUO
Synonyms	phospho TDP43, phospho(409/410)-TDP43, TARDBP, TDP43

Uniprot	Q13148
Gene Id	23435
Research Area	Epigenetics, Metabolism, Neuroscience

Form	liquid
Format	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Applications	ELISA, WB
Description	ELISA ; WB
Tested Application	WB: 1:500-1:2000

Manual	FNab06401.pdf

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SKU	Supplier No.	Size	Your price	Quantity
BHA10806393	FNab06401	100ug	$260		Add to Cart

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