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Home / Primary Antibodies / Polyclonal Antibodies

Phospho-STAT1 (Tyr701) antibody

SKU : BHA10810669

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Mfr.No.	FNab10880
Background	Signal transducer and transcription activator that mediates cellular responses to interferons(IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN(IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases(TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element(ISRE) to activate the transcription of IFN-stimulated genes(ISG), which drive the cell in an antiviral state. In response to type II IFN(IFN-gamma), STAT1 is tyrosine-and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor(GAF), migrates into the nucleus and binds to the IFN gamma activated sequence(GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
Clonality	polyclonal
Host	Rabbit
Immunogen	A phospho specific peptide corresponding to residues surrounding Y701 of human STAT1
Immunogen Region	A phospho specific peptide corresponding to residues surrounding Y701 of human STAT1
Isotype	IgG
Molecular Weight	80-90 kDa
Reactivity	Human
Recommended Dilution	WB: 1:500-1:1000
Synonyms	ISGF 3, STAT1, STAT91

Uniprot	P42224
Gene Id	6772
Research Area	Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology

Form	liquid
Purification	Immunogen affinity purified
Purity	>=95% as determined by SDS-PAGE
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

Tested Application	WB: 1:500-1:1000

Product Manual	<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10882.pdf" target="_blank">Data Sheet</ a>

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SKU	Supplier No.	Size	Your price	Quantity
BHA10810669	FNab10880	100ug	$300		Add to Cart

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