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Home / Primary Antibodies / IHC Antibodies

Phospho-SHC1 (Y427) Antibody

BHA10536321
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+1 866.986.9598
Email
orders@biohippo.com
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Uniprot P29353
Database Links

HGNC:10840

OMIM:600560

KEGG:hsa:6464

STRING:9606.ENSP00000401303

UniGene:Hs.433795
Function Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.
Pathway Chemokine signaling pathway ErbB signaling pathway Estrogen signaling pathway Focal adhesion Ras signaling pathway Natural killer cell mediated cytotoxicity Insulin signaling pathway Phospholipase D signaling pathway Neurotrophin signaling pathway
Tissue Specificity Widely expressed. Expressed in neural stem cells but absent in mature neurons.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Format Liquid
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Storage Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications WB, IHC, ELISA
Description WB ; IHC ; ELISA, WB ; ELISA ; IHC
Dilution

WB1:500-1:2000
IHC1:100-1:300
ELISA1:10000
Tested Application WB,IHC,ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/10000
Datasheet
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
SKU Supplier No. Size Your price Quantity
BHA10536321 CSB-PA000671 100ug $167
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BHA10536321 CSB-PA000671 50ug $100
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