Phospho-NMDAR2B (Tyr1336) Antibody

Mfr.No.	AF3426
Alternative Names	AW490526 ; EIEE27 ; Glutamate [NMDA] receptor subunit epsilon 2 ; Glutamate [NMDA] receptor subunit epsilon-2 ; Glutamate Receptor Ionotropic N Methyl D Aspartate 2B ; Glutamate Receptor Ionotropic N Methyl D Aspartate subunit 2B ; Glutamate receptor ionotropic NMDA2B ; Glutamate receptor subunit epsilon 2 ; Glutamate receptor, ionotropic, NMDA2B (epsilon 2) ; GRIN 2B ; GRIN2B ; hNR 3 ; hNR3 ; MGC142178 ; MGC142180 ; MRD6 ; N methyl D asparate receptor channel subunit epsilon 2 ; N methyl D aspartate receptor subtype 2B ; N methyl D aspartate receptor subunit 2B ; N methyl D aspartate receptor subunit 3 ; N-methyl D-aspartate receptor subtype 2B ; N-methyl-D-aspartate receptor subunit 3 ; NMDA NR2B ; NMDA R2B ; NMDAR2B ; NMDE2 ; NMDE2_HUMAN ; NME2 ; NR2B ; NR3 ;
Categories	Primary Antibodies ; Phospho Antibodies
Clonality	polyclonal
Description	N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.
Immunogen	A synthesized peptide derived from human NMDAR2B around the phosphorylation site of Tyrosine 1336.
Molecular Weight	Observed Mol.Wt.: 150kDa. Predicted Mol.Wt.: 167kDa.
Reactivity	Human, Mouse, Rat
Specificity	Phospho-NMDAR2B (Tyr1336) Antibody detects endogenous levels of NMDAR2B only when phosphorylated at Tyrosine 1336.
Subcellular Location	Cell membrane. Cell junction > synapse > postsynaptic cell membrane.

Antigen

Phospho-NMDAR2B (Tyr1336)

Uniprot

Q13224

Gene Id

2904

Sequence

10	20	30	40	50
MKPRAECCSP	KFWLVLAVLA	VSGSRARSQK	SPPSIGIAVI	LVGTSDEVAI
60	70	80	90	100
KDAHEKDDFH	HLSVVPRVEL	VAMNETDPKS	IITRICDLMS	DRKIQGVVFA
110	120	130	140	150
DDTDQEAIAQ	ILDFISAQTL	TPILGIHGGS	SMIMADKDES	SMFFQFGPSI
160	170	180	190	200
EQQASVMLNI	MEEYDWYIFS	IVTTYFPGYQ	DFVNKIRSTI	ENSFVGWELE
210	220	230	240	250
EVLLLDMSLD	DGDSKIQNQL	KKLQSPIILL	YCTKEEATYI	FEVANSVGLT
260	270	280	290	300
GYGYTWIVPS	LVAGDTDTVP	AEFPTGLISV	SYDEWDYGLP	ARVRDGIAII
310	320	330	340	350
TTAASDMLSE	HSFIPEPKSS	CYNTHEKRIY	QSNMLNRYLI	NVTFEGRNLS
360	370	380	390	400
FSEDGYQMHP	KLVIILLNKE	RKWERVGKWK	DKSLQMKYYV	WPRMCPETEE
410	420	430	440	450
QEDDHLSIVT	LEEAPFVIVE	SVDPLSGTCM	RNTVPCQKRI	VTENKTDEEP
460	470	480	490	500
GYIKKCCKGF	CIDILKKISK	SVKFTYDLYL	VTNGKHGKKI	NGTWNGMIGE
510	520	530	540	550
VVMKRAYMAV	GSLTINEERS	EVVDFSVPFI	ETGISVMVSR	SNGTVSPSAF
560	570	580	590	600
LEPFSADVWV	MMFVMLLIVS	AVAVFVFEYF	SPVGYNRCLA	DGREPGGPSF
610	620	630	640	650
TIGKAIWLLW	GLVFNNSVPV	QNPKGTTSKI	MVSVWAFFAV	IFLASYTANL
660	670	680	690	700
AAFMIQEEYV	DQVSGLSDKK	FQRPNDFSPP	FRFGTVPNGS	TERNIRNNYA
710	720	730	740	750
EMHAYMGKFN	QRGVDDALLS	LKTGKLDAFI	YDAAVLNYMA	GRDEGCKLVT
760	770	780	790	800
IGSGKVFAST	GYGIAIQKDS	GWKRQVDLAI	LQLFGDGEME	ELEALWLTGI
810	820	830	840	850
CHNEKNEVMS	SQLDIDNMAG	VFYMLGAAMA	LSLITFICEH	LFYWQFRHCF
860	870	880	890	900
MGVCSGKPGM	VFSISRGIYS	CIHGVAIEER	QSVMNSPTAT	MNNTHSNILR
910	920	930	940	950
LLRTAKNMAN	LSGVNGSPQS	ALDFIRRESS	VYDISEHRRS	FTHSDCKSYN
960	970	980	990	1000
NPPCEENLFS	DYISEVERTF	GNLQLKDSNV	YQDHYHHHHR	PHSIGSASSI
1010	1020	1030	1040	1050
DGLYDCDNPP	FTTQSRSISK	KPLDIGLPSS	KHSQLSDLYG	KFSFKSDRYS
1060	1070	1080	1090	1100
GHDDLIRSDV	SDISTHTVTY	GNIEGNAAKR	RKQQYKDSLK	KRPASAKSRR
1110	1120	1130	1140	1150
EFDEIELAYR	RRPPRSPDHK	RYFRDKEGLR	DFYLDQFRTK	ENSPHWEHVD
1160	1170	1180	1190	1200
LTDIYKERSD	DFKRDSVSGG	GPCTNRSHIK	HGTGDKHGVV	SGVPAPWEKN
1210	1220	1230	1240	1250
LTNVEWEDRS	GGNFCRSCPS	KLHNYSTTVT	GQNSGRQACI	RCEACKKAGN
1260	1270	1280	1290	1300
LYDISEDNSL	QELDQPAAPV	AVTSNASTTK	YPQSPTNSKA	QKKNRNKLRR
1310	1320	1330	1340	1350
QHSYDTFVDL	QKEEAALAPR	SVSLKDKGRF	MDGSPYAHMF	EMSAGESTFA
1360	1370	1380	1390	1400
NNKSSVPTAG	HHHHNNPGGG	YMLSKSLYPD	RVTQNPFIPT	FGDDQCLLHG
1410	1420	1430	1440	1450
SKSYFFRQPT	VAGASKARPD	FRALVTNKPV	VSALHGAVPA	RFQKDICIGN
1460	1470	1480
QSNPCVPNNK	NPRAFNGSSN	GHVYEKLSSI	ESDV

Concentration	1mg/ml
Format	Liquid
Purification	The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
Storage Condition	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.