The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
Clonality
polyclonal
Host
Rabbit
Immunogen
calcium/calmodulin-dependent protein kinase II alpha
Immunogen Region
calcium/calmodulin-dependent protein kinase II alpha
Isotype
IgG
Molecular Weight
54 kDa
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1:500-1:2000
Synonyms
CaM kinase II subunit alpha, CaMK II subunit alpha, CAMK2, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMKA, CaMKII alpha, KIAA0968
Uniprot
Q9UQM7
Form
liquid
Purification
Immunogen affinity purified
Purity
>=95% as determined by SDS-PAGE
Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)
Tested Application
WB: 1:500-1:2000
Product Manual
<a href="https://www.fn-test.com/content/uploads/product/manuals/antibody/FNab10481.pdf" target="_blank">Data Sheet</ a>